解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Polymorphisms such as single-nucleotide polymorphisms (SNPs) and insertions/deletions (Indels) can be associated with phenotypic traits and be used as markers for disease diagnosis. Identification of these genetic variations within laboratory mice is crucial to improve our understanding of the genetic background of th...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1353
更新日期:2012-03-01 00:00:00
abstract::2-Arylbenzothiazoles are an important class of bicyclic privileged substructures present in various natural or synthetic compounds that have been shown to possess anticancer, antifungal, antibacterial, anti-inflammatory, and antiallergic activities. This study examined the antiproliferative properties of 2-(3,5-dihydr...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1363
更新日期:2012-03-01 00:00:00
abstract::Head and neck cancers (head and neck squamous cell carcinomas [HNSCC]) are a heterogeneous group of neoplasms with varying presenting symptoms, treatment, and expected outcome. There is a need to find an effective way of its treatment at the molecular level. Thus, we should identify the mechanism of cancer cell respon...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1325
更新日期:2012-03-01 00:00:00
abstract::Palindromati, the massive host-edited synthetic palindromic contamination found in GenBank, is illustrated and exemplified. Millions of contaminated sequences with portions or tandems of such portions derived from the ZAP adaptor or related linkers are shown (1) by the 12-bp sequence reported elsewhere, exon Xb, 5' CC...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1339
更新日期:2012-02-01 00:00:00
abstract::Several reports have suggested the importance of p73 polymorphisms in tumor behavior. We investigated the role of a p73 gene polymorphism in the susceptibility to cervical lesions in a southwestern European population. Peripheral blood samples were obtained from Radiotherapy and Gynaecology Departments of Portuguese I...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1294
更新日期:2012-02-01 00:00:00
abstract::Glucose-stimulated insulin gene transcription is mainly regulated by a 340-bp promoter region upstream of the transcription start site by beta-cell-enriched transcription factors Pdx-1, MafA, and NeuroD1. Previous studies have shown that histone H4 hyperacetylation is important for acute up-regulation of insulin gene ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1336
更新日期:2012-01-01 00:00:00
abstract::An increasing amount of evidence suggests that interleukin-18 (IL-18) plays a pivotal role in the pathophysiology of schizophrenia. However, association between single nucleotide polymorphism of IL-18 and the risk of schizophrenia has not been clarified. This study examined whether two promoter polymorphisms -137 G/C ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1221
更新日期:2011-11-01 00:00:00
abstract::Single-nucleotide polymorphisms (SNPs) in pre-miRNAs may alter microRNA (miRNA) expression levels or processing and contribute to susceptibility to a wide range of diseases. We investigated the correlation between four SNPs (rs11614913, rs3746444, rs2910164, and rs229283) in pre-miRNAs and the risk of asthma in 220 as...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2010.1164
更新日期:2011-11-01 00:00:00
abstract::Mutations in the mitochondrial genome (mtDNA) are associated with different types of cancer, specifically colorectal cancer (CRC). However, few studies have been performed on precancerous lesions, such as ulcerative colitis (UC) lesions and adenomatous polyps (AP). The aim of this study was to identify mtDNA mutations...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2010.1186
更新日期:2011-11-01 00:00:00
abstract::Hearing loss in Ménière's disease (MD) is associated with loss of spiral ganglion neurons and hair cells. In a guinea pig model of endolymphatic hydrops, nitric oxide synthases (NOS) and oxidative stress mediate loss of spiral ganglion neurons. To test the hypothesis that functional variants of NOS1 and NOS2A are asso...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1259
更新日期:2011-09-01 00:00:00
abstract::FOXO3 is a member of the Forkhead box class O (FOXO) transcription factor family that modulates the transcription of target genes in a variety of cellular functions in lower animals to mammals. It has been implicated in the attenuation of insulin-signaling pathways, including having a potential role in lifespan contro...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2010.1193
更新日期:2011-07-01 00:00:00
abstract::Adipose-derived stem cells/adipose-derived progenitor cells (ADPCs) are multipotent stem cells that can differentiate in vitro into many cell types. However, the vast majority of experimental materials were obtained from human, mouse, rabbit, and other mammals but rarely from poultry. In this study, ADPCs were isolate...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2010.1154
更新日期:2011-07-01 00:00:00
abstract::MicroRNAs (miRNA) are a class of small noncoding RNA molecules that have been implicated in a wide variety of cellular functions through post-transcriptional regulations on target genes. Common genetic variants (single-nucleotide polymorphisms, SNPs) in pre-miRNA genes may alter their expression and/or maturation effe...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2010.1159
更新日期:2011-06-01 00:00:00
abstract::NADPH: quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside: quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze reductive activation of carcinogens from cigarette smoke, such as nitrosamines and heterocyclic amines. These enzymes also protect cells against oxidative damage from reactive ox...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2010.1115
更新日期:2011-05-01 00:00:00
abstract::Studies of the epigenome have attracted little interest in nephrology, especially in uremia. Several lines of evidence have suggested that there are links between genomic DNA hypomethylation and cardiovascular complications in uremia patients. However, to date, our knowledge about the alterations in histone methylatio...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2010.1076
更新日期:2011-03-01 00:00:00
abstract::Genes involved in the production of nitric oxide (NO) have been suggested as genetic factors for migraine. It has been studied whether polymorphisms in the genes encoding for different types of NO synthase (NOS) could be involved in the liability to migraine; however, most studies yield negative results. The pentanucl...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2010.1102
更新日期:2011-02-01 00:00:00
abstract::Clusterin (CLU) and clathrin assembly lymphoid myeloid (CALM) protein are implicated in the function of neuronal synapses. However, to our knowledge, whether they play roles in the maldevelopment of synaptic pathways in schizophrenia has not been studied. The purpose of this study was to examine whether single nucleot...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2010.1075
更新日期:2010-12-01 00:00:00
abstract::A safe and effective adjuvant is important to develop vaccines against highly pathogenic avian influenza virus. Chitosan, a derivative from the natural amino polysaccharide chitin, has been proved to be an effective adjuvant for inactivated influenza virus vaccine. In this study, protective immunity in mice provided b...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2009.0977
更新日期:2010-09-01 00:00:00
abstract::Temporal coordination of meiosis with spermatid morphogenesis is crucial for successful generation of mature sperm cells. We identified a recessive male sterile Drosophila melanogaster mutant, mitoshell, in which events of spermatid morphogenesis are initiated too early, before meiotic onset. Premature mitochondrial a...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2009.0989
更新日期:2010-09-01 00:00:00
abstract::The serotonin (5-hydroxytryptamine) transporter (5HTt) gene has been reported to be associated with suicidal behavior. In this study, we have investigated the 5' promoter region (i.e., 5HTt gene-linked polymorphic region [5-HTTLPR]) and a 17-base pair variable number of tandem repeats polymorphism in the 5HTt gene for...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2010.1031
更新日期:2010-08-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) production is regulated by growth factors and inflammatory cytokines, and VEGF plays a role in migraine. We examined for the first time whether three functional polymorphisms in the promoter region of VEGF gene (C(-2578)A, G(-1154)A, and G(-634)C) and VEGF haplotypes are assoc...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2010.1025
更新日期:2010-07-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis, which is crucial for development and metastasis of tumors including hepatocellular carcinoma (HCC), and elevated VEGF levels in serum and tissues have been known to be related with poor prognosis in patients with HCC. Polymorphisms in VEGF ma...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2009.1015
更新日期:2010-07-01 00:00:00
abstract::The micronucleus (MN) assay in exfoliated buccal cells is a useful and minimally invasive method for monitoring genetic damage in humans exposed to occupational and environmental agents. The MN test is used as an indicator of genotoxic exposition, since it is associated with chromosome aberrations. An increased mutati...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2009.0996
更新日期:2010-06-01 00:00:00
abstract::The potential association of variant surface glycoprotein (VSG) gene expression with clonal expression of virulence in African trypanosomes was addressed. Two populations of clonally related trypanosomes, which differ dramatically in virulence for the infected host, but display the same apparent VSG surface coat pheno...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2009.0991
更新日期:2010-05-01 00:00:00
abstract::The p53 tumor suppressor gene is frequently mutated in multiple human cancers, leading to loss of wild-type p53 (wt-p53)-dependent functions and tumorigenesis. p53 gene therapy is used to induce apoptosis in human cancer cells and tumors. Activation of nuclear factor kappa B (NF-kappaB) causes resistance to both chemo...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2008.0839
更新日期:2009-12-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a life-threatening disease that is often associated with chronic infection by hepatitis B and C viruses. Genetic polymorphisms have been reported to alter the risk for HCC development. Genetic studies based on the haplotype have an increased power for detecting disease associations co...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2009.0921
更新日期:2009-11-01 00:00:00
abstract::Dengue virus serotype 3 (DENV-3) was associated with severe dengue epidemics in Thailand during 1973-1999. We studied Thai DENV-3 viruses isolated from hospitalized children in Bangkok with differing disease severity during that period. Viruses were sequenced at their 5' and 3' untranslated regions (UTRs), which are r...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2008.0835
更新日期:2009-10-01 00:00:00
abstract::The aims of our research involved to investigate DYS-14 copy number variations in healthy males, to quantify extracellular DNA in maternal circulation in normal versus complicated pregnancies, and to study variations in the DYS-14 copy number in extracellular male fetal DNA. Fifty-five healthy males, 43 uncomplicated ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2009.0855
更新日期:2009-07-01 00:00:00
abstract::Apicomplexa is a phylum within the kingdom Protista that contains some of the most significant threats to public health. One of the members of this phylum, Toxoplasma gondii, is amenable to molecular genetic analyses allowing for the identification of factors critical for colonization and disease. A pathway found to b...
journal_title:DNA and cell biology
pub_type: 杂志文章,评审
doi:10.1089/dna.2009.0853
更新日期:2009-06-01 00:00:00
abstract::The expression of growth factors, proteolytic enzymes, fibrogenic factors, and cytokines is altered in the Helicobacter pylori-infected gastric mucosa. Therefore, we aimed to evaluate the association of functional promoter variants of transforming growth factor (TGF)-B1 and matrix metalloproteinase (MMP)-7 genes with ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2008.0842
更新日期:2009-06-01 00:00:00
abstract::Growth factors are important mediators of proliferation. Deregulation in growth factor mechanisms as well as in its receptors will contribute to cancer development. One of the most important is the epidermal growth factor (EGF), which is encoded by EGF gene. A functional polymorphism at position 61 (A/G) is associated...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2008.0823
更新日期:2009-05-01 00:00:00
abstract::Design and synthesis of new small molecules binding to double-stranded RNA necessitate complete understanding of the molecular aspects of the binding of many existing molecules. Toward this goal, in this work we evaluated the biophysical aspects of the interaction of a DNA intercalator (proflavine) and a minor groove ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2008.0838
更新日期:2009-04-01 00:00:00
abstract::Epulopiscium sp. type B, a member of the Firmicutes, is a large (up to 300 microm), cigar-shaped bacterial symbiont of surgeonfish that propagates itself by forming multiple intracellular offspring. This unusual form of reproduction is an apparent modification of a developmental program used by some Firmicutes to prod...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2008.0801
更新日期:2009-02-01 00:00:00
abstract::Eaf2 encodes a tumor suppressor that plays multiple functions in transcriptional activation, apoptosis, and embryonic development. In this study, we utilized GFP-EAF2 fusion protein to describe the dynamic subcellular movement of Eaf2. GFP-EAF2 is preferentially localized to the nucleus, and in the presence of ELL, it...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2008.0733
更新日期:2008-12-01 00:00:00
abstract::CXXC finger protein 1 (CFP1) is a component of the Setd1A and Setd1B methyltransferase complexes, localizes to euchromatic regions of the genome, and specifically binds unmethylated CpG dinucleotides in DNA. Murine embryos lacking CFP1 exhibit peri-implantation lethality, a developmental time that correlates with glob...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2007.0714
更新日期:2008-10-01 00:00:00
abstract::It is well known that the positively charged polyamines have a DNA-stabilizing function and that polyamine depletion alters chromatin function. We have previously shown that polyamine depletion causes an S phase prolongation, and others have shown that there is an accumulation of Okazaki-like fragments in polyamine-de...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2008.0750
更新日期:2008-09-01 00:00:00
abstract::In our previous study, a kind of novel hybrid immunoglobulin (Ig)-binding proteins (IBPs) was obtained with the characteristic structure of alternately arranged Finegoldia magna (formerly Peptostreptococcus magnus) protein L (P. magnus protein L, PpL) B3 domain (B3) and Staphylococcal protein A (SpA) D domain (D). In ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2007.0708
更新日期:2008-08-01 00:00:00
abstract::Epigenetic modifications, especially alteration in DNA methylation, are increasingly being recognized as a key factor in the pathogenesis of complex disorders, including atherosclerosis. However, there are limited data on the epigenetic changes in the coronary artery disease (CAD) patients. In the present study we eva...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2007.0694
更新日期:2008-07-01 00:00:00
abstract::The pathogenic strains of Vibrio cholerae that cause acute enteric infections in humans are derived from environmental nonpathogenic strains. To track the evolution of pathogenic V. cholerae and identify potential precursors of new pathogenic strains, we analyzed 324 environmental or clinical V. cholerae isolates for ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2008.0737
更新日期:2008-07-01 00:00:00
abstract::Apoptosis, which is usually accompanied by DNA degradation, is important not only for the homeostasis of metazoans but also for mammalian development. If DNA is not properly degraded in these processes, it can cause diverse diseases, such as anemia, cataracts, and some autoimmune diseases. A large effort has been made...
journal_title:DNA and cell biology
pub_type: 杂志文章,评审
doi:10.1089/dna.2007.0691
更新日期:2008-05-01 00:00:00